7. β-Glucan as an immune activator and a carrier in the construction of a synthetic MUC1 vaccine
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作者:Hanxuan Wang, Bing Yang, Yinglu Wang, Fen Liu, Alberto Ferna ´ndez-Tejada * and Suwei Dong *
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发布时间: 2018-12-03
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1381 次浏览
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Chem. Commun. 2019, 55, 253.
Hanxuan Wang, Bing Yang, Yinglu Wang, Fen Liu, Alberto Ferna ´ndez-Tejada * and Suwei Dong *
We describe the preparation of a cancer vaccine candidate by conjugating a MUC1 peptide antigen to the β-glucan polysaccharide, which serves both as a carrier and an immune activator. In contrast to amorphous polysaccharides, peptide–β-glucan conjugates form uniform nanoparticles that facilitate the delivery of antigens and binding to myeloid cells, thus leading to the activation of both innate and adaptive immunity.
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