8. Engineering of Therapeutic Polypeptides through Chemical Synthesis: Early Lessons from Human Parathyroid Hormone and Analogues
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作者: Suwei Dong, Shiying Shang, Jianfeng Li, Zhongping Tan, Thomas Dean, Akira Maeda, Thomas J. Gardella, and Samuel J. Danishefsky*
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发布时间: 2012-08-14
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J. Am. Chem. Soc. 2012, 134, 15122-15129.
Suwei Dong, Shiying Shang, Jianfeng Li, Zhongping Tan, Thomas Dean, Akira Maeda, Thomas J. Gardella, and Samuel J. Danishefsky*
Application of chemical synthesis to gain access to high purity hPTH as well as more stable analogues was accomplished through a menu of extended NCL followed by metal free dethiylation.
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