7. Advances in Proline Ligation
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作者: Steven D. Townsend, Zhongping Tan, Suwei Dong, Shiying Shang, John A. Brailsford, and Samuel J. Danishefsky*
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发布时间: 2012-02-15
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J. Am. Chem. Soc. 2012, 134, 3912-3916.
Steven D. Townsend, Zhongping Tan, Suwei Dong, Shiying Shang, John A. Brailsford, and Samuel J. Danishefsky*
Application of native chemical ligation logic to the case of an N-terminal proline is described. Two approaches were studied. One involved incorporation of a 3R-substituted thiyl-proline derivative. Improved results were obtained from a 3R-substituted selenol function, incorporated in the context of an oxidized dimer.
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