3. Enantioselective Synthesis of (+)‐Chamaecypanone C: A Novel Microtubule Inhibitor
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作者:Suwei Dong, Ernest Hamel, Ruoli Bai, David G. Covell, John A. Beutler, and John A. Porco Jr.
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发布时间: 2009-01-30
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Angew. Chem. Int. Ed. 2009, 48, 1494-1497.
Suwei Dong, Ernest Hamel, Ruoli Bai, David G. Covell, John A. Beutler, and John A. Porco Jr.
A bicycle built for tubulin : The total synthesis of (+)‐chamaecypanone C has been achieved by using a tandem retro‐Diels–Alder/Diels–Alder cascade reaction (see scheme). Initial biological studies demonstrate that (+)‐chamaecypanone C is an inhibitor of tubulin assembly and binds at the colchicine site.
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